Pan-B cell marker negative B cell lymphomas are rare, most commonly observed in ALK positive large B cell lymphoma (ALK + LBCL), plasmablastic lymphoma (PBL), primary effusion lymphoma (PEL), HHV8+ large B cell lymphoma (HHV8+ LBCL), and unclassifiable large B cell lymphoma. Here, ALK is linked to B-cell non-Hodgkin lymphoma.