BRCA2 and breast cancer: Within the HRR genes other than BRCA1 and RAD51C, we found elevated HRD scores and/or proportion of Signature 3 in the single BRCA2-methylated BC, PALB2-methylated LUSC and BRIP1-methylated LIHC cases, but not in the two BRIP1-methylated UCEC cases (Figure 6A, B).