BRCA1 and cancer: Analysing selected promoter probes of BRCA1 and RAD51C, we identified promoter methylation of BRCA1 (meBRCA1) or RAD51C (meRAD51C) (Supplementary Figure S2, S3 and S8) in 15 out of 23 cancer types (Figure 1A, B, Supplementary Table S2).