Strikingly within TGCT, the methylation profiles among samples with meBRCA1 or meRAD51C or combined meBRCA1 and meRAD51C showed low methylation signal across all the BRCA1/RAD51C promoter probes examined (Supplementary Figure S11), suggesting a distinctive methylation pattern of these two genes in TGCT compared to the other cancer types. The gene discussed is BRCA1; the disease is cancer.