Our findings indicate that CSNB genes are predominantly present in rod- or BC-specific regulons, such as SLC24A1 in the CRX regulon, GNB3 in the RAX2 regulon, and GRM6 in the OTX2 regulon (Figure 4C, Supplementary Figure 2E), whereas GRMP was specifically highly expressed only in BCs (Figure 2A). This evidence concerns the gene OTX2 and breast cancer.