Rodent (Crb1, Lrat, Mertk, Rpe65, and Rpgrip1), avian (Gucy2D), and canine (Rpe65) models for LCA and profound visual impairment have been successfully corrected employing adeno-associated virus or lentivirus-based gene therapy (den Hollander et al., 2008). The gene discussed is CRB1; the disease is Visual impairment.