Induces the expression of GRP78, p‐PERK, p‐eIF2α, ATF‐4, CHOP, and DR5. In gefitinib‐resistant ovarian cancer cells, 6‐shogaol upregulates N‐cadherin, vimentin, Slug, and Snail, while downregulated E‐cadherin overcoming gefitinib resistance. The gene discussed is CDH1; the disease is ovarian carcinoma.