Induces the expression of GRP78, p‐PERK, p‐eIF2α, ATF‐4, CHOP, and DR5. In gefitinib‐resistant ovarian cancer cells, 6‐shogaol upregulates N‐cadherin, vimentin, Slug, and Snail, while downregulated E‐cadherin overcoming gefitinib resistance. This evidence concerns the gene CDH2 and ovarian carcinoma.