In conclusion, the results of the present study showed that 8 weeks of synbiotic supplementation, consisting of two kinds of bacteria strains and FOS, increased fullness sensation between the two groups, while it had no significant beneficial effects on FBS, fasting insulin level, HOMA‐IR, QUICKI, TNF‐α, and hs‐CRP in patients with MetS. The gene discussed is FOS; the disease is metabolic syndrome.