We assessed the effects of synbiotic supplementation on fasting blood sugar (FBS), fasting insulin, homeostasis assessment model for insulin resistance (HOMA‐IR), quantitative insulin sensitivity check index (QUICKI), tumor necrosis factor‐α (TNF‐ α), high‐sensitivity C‐reactive protein (hs‐CRP), and appetite among metabolic syndrome (MetS) patients. This evidence concerns the gene MAP3K14 and metabolic syndrome.