Therefore, the present study aims to evaluate the effects of supplementation with synbiotics (B. coagulans and B. indicus as probiotics and fructooligosaccharides [FOS] as a prebiotic) on fasting glucose level, fasting insulin levels, insulin resistance, insulin sensitivity, TNF‐α, and high‐sensitivity C‐reactive protein (hs‐CRP), and appetite among MetS patients. The gene discussed is INS; the disease is metabolic syndrome.