Based on our recent findings, which demonstrated an elevated susceptibility of SLE subjects with anti-Ro 60, La, and Ro 52 antibodies to develop antioxidized LDL (ox-LDL) antibodies (26), we formulated the hypothesis that atherosclerotic plaque would be associated with antioxidized LDL (anti-oxLDL)/antilipoprotein lipase (ALPL) in a specific SLE autoantibody subset (anti-Ro60 positive, anti-RNP positive, anti-SmRNP positive, or extractable nuclear antigen antibody negative). Here, ALPL is linked to systemic lupus erythematosus.