Diabetic macular edema (DME) is the most common cause of DR-related vision loss causing abnormal thickening in the retina yielding to visual acuity weakening or loss.19,20 The estimated prevalence within the DM population is 34.6% for DR and 6.8% for DME.21 Like DM, DR is treated with hypoglycemics; however, the treatment of DME includes intravitreal anti–vascular endothelial growth factor and/or corticosteroid injections, which can cause ADEs such as cataracts, intraocular pressure rise, retinal detachment, endophthalmitis, and vitreous hemorrhage. The gene discussed is VEGFA; the disease is diabetes mellitus.