In comparison, after addition of BRAFV600E mutation to Min mouse model, called ETBF‐colonized BRAFV600E Lgr5Cre Min mouse model, results were typified by a mid‐proximal colon tumors emergence, CpG island DNA hypermethylation, high infiltration of CD8+ T cells, interferon (IFN)‐γ signatures expression, and sensitive to anti‐programmed cell death ligand 1 (PD‐L1) treatment, which is consistent with findings in melanomas from patients that responded to anti‐programmed cell death protein 1 (PD‐1) checkpoint therapy.64 This evidence concerns the gene CD274 and digestive system cancer.