To illustrate, it has been investigated that expression of signal transducer and activator of transcription 1 (STAT1) in CMS1 pertaining to high infiltration level of CD8+ T cells and activation of T cell receptor signaling pathway, which drives a hyper‐immunogenic TME and strong anti‐tumor immune cell infiltration in CMS1, while the others displayed adverse immunogenicity.54 The gene discussed is CD8A; the disease is neoplasm.