The Cancer Genome Atlas (TCGA) database analysis showed that SHISA3 expression level was markedly downregulated in 14 solid tumor types (Figure 1A), which is in agreement with previous reports.[22, 23, 24, 25, 26] By analyzing gene expression correlation in LUAD, LUSC, PAAD, SKCM, COAD, LIHC, and KIRP using the TIMER 2.0 website, we found that higher expression of SHISA3 positively correlated with M1 type macrophage infiltration and negatively correlated with MDSC infiltration in most types of these cancers (Figure 1B). Here, SHISA3 is linked to cancer.