SHISA3 and neoplasm: Tumor cells overexpress “don't eat me” signals to escape phagocytosis by macrophages.[34] Thus, effectively re‐educating M2‐like TAMs into the “eat me” phenotype plays a crucial role in tumor immunotherapy.[35] We observed a striking increase in the phagocytosis of latex beads when Shisa3 was overexpressed in macrophages (Figure S8D, Supporting Information).