SHISA3 and neoplasm: Therefore, we delivered Shisa3 mRNA to the tumor microenvironment by nanoparticles.[47] This method has a dual function: on the one hand, after being engulfed by macrophages, Shisa3 can induce its inflammatory M1 polarization, improve the antigen presentation function of macrophages, and restore the infiltration and activity of T cells in tumors; on the other hand, Shisa3 can also be delivered to tumor cells, exerting its function as a tumor suppressor gene.