In addition, we conducted a comprehensive analysis of the expression features of inhibitory receptors (IRs), expression of SHISA3 was positively correlated with the expression of immune checkpoint genes, such as CD274 (encoding PD‐L1), TIGIT, LAG3, CTLA4, and PDCD1 (encoding PD‐1) in a variety of types of cancer (Figure 1C).[28] These results showed that tumor suppressor SHISA3 may play a critical role in antitumor immunity. This evidence concerns the gene CTLA4 and cancer.