PRKAB1 and obesity due to melanocortin 4 receptor deficiency: In this study, we analyzed the physiological indexes of the mice and found that after 4 weeks of electroacupuncture treatment, the body weight, food intake, and water intake of mice in the Acu + AMPK antagonist group and the Acu + ACC antagonist group decreased compared with those in the first week, suggesting that electroacupuncture treatment improved the obesity and excessive food and water intake in T2DM with NAFLD mice.