ATF4 and type 2 diabetes mellitus: The results of this experiment are consistent with other studies in this field, such as liraglutide may improve T2DM-associated NAFLD by activating the AMPK/ACC signaling pathway [46]; EA at ST40 and ST36 can significantly improve the liver function of NAFLD rats, and its mechanism is related to the PERK/ATF4/CHOP signal pathway, which can inhibit endoplasmic reticulum stress and protect the liver [47].