To investigate the aberrant expression of NuP in breast cancer, a harmonised standardised pan-cancer dataset was downloaded from the UCSC (https://xenabrowser.net/) database as follows: TCGA BRCA (T = 1092, N = 113), from which the expression of the ENSG00000115053 (NCL) was further extracted from the specimen data, revealing that NCL was dramatically up-regulated in breast cancer (Fig. 1A). This evidence concerns the gene NUCLEOLIN and cancer.