ADAM8 and pancreatic neoplasm: Other relevant studies also suggested that plasma exosomes microRNAs (miR-409, miR-191, miR-21, miR-451a, miR-19b, miR-335-5p, miR-340-5p, miR-451,miR-720), mRNAs (CK18, CD63, FGA, KRT19, HIST1H2BK, ITIH2, MARCH2, CLDN1, MAL2, TIMP1, WASF2, and ARF6), small nucleolar RNAs (SNORA74A and SNORA25), and proteins (ZIP4, EphA2, ALIX, ADAM8) could assist to pancreatic cancer diagnosis [120–135].