However, another study suggested that circulating exosomes GPC1 was not diagnostic for pancreatic cancer, but indicated high levels of miR-181a, miR-10b, miR-21, miR-30c, and low levels of miR-let7a in plasma exosomes could effectively differentiate pancreatic cancer from healthy donors and chronic pancreatitis patients [119]. This evidence concerns the gene GPC1 and chronic pancreatitis.