These 31 genes were involved in epigenetic regulation (KMT2C, SETD2, EP300, KMT2D, TET2, DNMT3A, KMT2A, etc.), tumor suppression (FAT1, BCOR, BCORL1, ETV6, ARID1A, ATM, ARID2) and signaling pathways (NOTCH1, NOTCH2, TNFAIP3, NF1, TNFRSF14, MYD88, KLHL6, PDGFRB, SPEN, TET2, FAS, JAK3, NFKBIE, MTOR, RELN, CIITA, APC). The gene discussed is RELN; the disease is neoplasm.