SPEN and neoplasm: These 31 genes were involved in epigenetic regulation (KMT2C, SETD2, EP300, KMT2D, TET2, DNMT3A, KMT2A, etc.), tumor suppression (FAT1, BCOR, BCORL1, ETV6, ARID1A, ATM, ARID2) and signaling pathways (NOTCH1, NOTCH2, TNFAIP3, NF1, TNFRSF14, MYD88, KLHL6, PDGFRB, SPEN, TET2, FAS, JAK3, NFKBIE, MTOR, RELN, CIITA, APC).