ROCK1 and breast cancer: The level of Bcl-2 in MDA-MB-231 breast cancer cells treated with GluOC was significantly increased, but Bax, cl-caspase3 and cl-caspase9 were significantly reduced, and GluOC blocked the decrease in Bcl-2 and increase in Bax, cl-caspase3 and cl-caspase9 induced by ROCK1 (Fig. 3c-g).