For example, LPS- and PolyI:C- specific expressed genes were significantly enriched for GWAS signals associated with inflammatory and immune-related diseases in humans (e.g., Crohn's disease, inflammatory bowel disease, and ulcerative colitis), whereas EM-specific expressed genes were predominantly enriched for metabolism-related GWAS signals, such as lipoprotein A and gamma-glutamyl transferase, Shared genes were significantly enriched in GWAS signaling with inflammatory bowel disease, type 2 diabetes, and lipoproteinA (Fig. 6A). Here, LPA is linked to Crohn disease.