VWF and Cushing syndrome due to macronodular adrenal hyperplasia: For example, observational studies indicated that patients diagnosed with hyperthyroidism (or with elevated free thyroxine [FT4]) and hypercortisolism (e.g., Cushing’s syndrome) were associated with increased coagulation factors (e.g., FVIII, FIX, FX) and von Willebrand factor (VWF), leading to a greater risk of developing VTE [2, 5–8].