ADCY9 and neoplasm: In epithelial tumors, the ZEB1 protein is oncogenic because it promotes EMT not only directly (by repressing the transcription of miR-200 family), but also indirectly: it induced the transcription of Integrin A1 mRNA, which in turn sponges the tumor-suppressive miR-181b away from Adenylyl Cyclase 9 (ADCY9) mRNA.