In turn, PP-1 is a serine/threonine phosphatase mainly involved in chromosome decondensation at mitosis exit.108 PNUTS is a positive modulator of PP-1 activity, thereby favoring the re-entry into interphase.109 It is also involved in DNA damage repair.110 In the context of breast cancer, PPP1R10 gene expresses lncRNA-PNUTS as well, due to an alternative 3′ splice site that is located in exon 12 and breaks the ORF encoding PNUTS protein. The gene discussed is PPP1R10; the disease is breast cancer.