As a result, the levels of ADCY9 protein increase, as well as those of cyclic AMP, which favors metastatic dissemination.157 In melanoma ZEB2 behaves as a tumor suppressor not only because ZEB2 protein activates MITF-dependent differentiation program,158 but also because ZEB2 3′UTR has PTEN mRNA as ceRNA partner.151. This evidence concerns the gene ZEB2 and neoplasm.