MYC in particular is a key stemness-associated transcription factor26 previously implicated in histological transformation,1,27 known to be a driver of SCLC tumors28,29 and also associated with resistance to targeted therapies.30 Based on its role as promoter of stem-like features, we hypothesized that it might function as an early actor in NE transformation, facilitating deprogramming and reprogramming of adenocarcinoma into a NE state. This evidence concerns the gene MYC and adenocarcinoma.