MYC and small cell lung carcinoma: To study whether MYC overexpression may promote the acquisition of chemotherapy resistance at a longer term, we overexpressed wild type MYC and MYCT58A in two SCLC cell lines with limited or no endogenous MYC expression (H146 and H69, Supplementary Fig s6h) that were treated with cisplatin alone or in combination with simurosertib (Supplementary Fig s6j).