RB1 and neoplasm: Remarkably, analysis for the whole The Cancer Genome Atlas (TCGA) PanCancer dataset (n = 10,071) confirmed that TP53- or RB1-inactivated tumors exhibit higher CDC7 levels than TP53/RB1-wild type tumors, and that double TP53/RB1-inactivated tumors exhibit even higher CDC7 expression (Supplementary Fig. s2b), suggestive of a tumor-agnostic, universal interplay between these tumor suppressors and CDC7 dependency.