CDC7 and small cell lung carcinoma: We leveraged a previously reported druggable genome single guide (sg) RNA library with ~14,000 sgRNAs targeting ~2300 genes encoding targets of known pharmacological inhibitors in clinical development or The Food and Drugs Administration (FDA)-approved drugs.19 Deep sequencing analyses comparing sgRNA abundance of final timepoint versus day 0 identified multiple sgRNAs targeting CDC7 among the top hits depleted in the screen (Fig. 1b and Supplementary Data S1), thus nominating this gene as a potential dependency in T-SCLC.