We observed significant positive correlations of CDC7 expression with an extensively used NE gene signature, as well as with key NE markers (Supplementary Fig. s5e), where cell lines derived from tumors with NE features showed high CDC7 expression, suggestive of an association of high CDC7 expression and NE tumor phenotype beyond SCLC and NEPC. The gene discussed is CDC7; the disease is small cell lung carcinoma.