After characterizing the CDC7 protein expression levels in our SCLC PDX platform including PDX derived from treatment-naïve and treated patients (Supplementary Fig. s5c), we selected 3 treatment-naïve PDX models with high (H-score>150), intermediate (150 > H-score>50) and low (H-score<50): Lx1231 (SCLC-A), Lx33 (SCLC-N), and Lx276 (SCLC-A), respectively. Here, CDC7 is linked to small cell lung carcinoma.