CDC7 and small cell lung carcinoma: Additionally, generation of isogenic SCLC cell lines with CDC7 knock out (KO) (Supplementary Fig. s1b) or overexpression (Supplementary Fig. s1c) indicated that CDC7 expression was associated with increased proliferation (Supplementary Fig. s1d, e) and colony formation in soft agar assays (Supplementary Fig s1f, g).