CDC7 and small cell lung carcinoma: Previous reports have suggested a role for CDC7 in chemoresistance in a variety of settings, including breast, ovarian, pancreatic and non-SCLC tumors.16 A recent report showed that in vitro-induced chemoresistance can be reverted by the CDC7 inhibitor XL413 in SCLC cell lines.33 We sought to further assess whether cytotoxic therapies for SCLC might be augmented by CDC7 inhibition.