Definitions were based on CD8+T cell densities in the tumor center, tumor fields, and invasive margin, as reported by Gruosso et al in breast cancer23 and reviewed by Tiwari et al. 2414 tumors (48%) were assigned as inflamed, fully infiltrated tumors, defined by tumors with a CD8+T cell density in the tumor center of more than 100 cells/mm2 as well as a density in tumor fields of more than the median of 82.8 cells/mm2 (figure 2B). The gene discussed is CD8A; the disease is neoplasm.