RGS5 and Stroke: In addition, we utilized RGS5+/gfp mice, expressing GFP upon RGS5 promotor activity to evaluate RGS5 expression in pericytes.30 RGS5 is a commonly used marker for pericytes that has been shown to be upregulated under ischemic conditions and specifically expressed by mural cells in the brain.22,23 In these mice, we observed a similar expression pattern showing an increased number of GFP+ cells from 1 hour after stroke (Supplementary Figure 1).