TP53 and colorectal carcinoma: Notably, TP53 demonstrated a higher mutation frequency in the High-Mg group for both left- and right-sided CRC, whereas APC exhibited a higher mutation frequency exclusively in the High-Mg group of left-sided CRC (72% cases in High-Mg group vs. 20% cases in Low-Mg group) but not right-sided CRC (Figure 2K).