CARD11 and colorectal carcinoma: Among the identified 7173 mutated genes with fewer than 5000 amino acids in 62 paired samples, the mutation frequencies of 162 genes were associated with Mg content, of which 160 genes exhibited higher mutation frequencies in the Low-Mg group (Figure 2G and H; Table S2), including six known CRC driver genes, KMT2C, BCL9, ERBB3, EP300, FAT3, and CARD11 (Table S2) [45].