According to Schmiemann V, et al, RASSF1A hypermethylation assays performed with QMSP on bronchial aspirates were correctly confirmed in 88% and 25% of cases with highly doubtful or suspicious cytology, respectively, and this technique proved to be a rather helpful diagnostic tool in cases of peripheral lung cancers where simultaneous cytology and histology tests yielded negative results [24]. This evidence concerns the gene RASSF1 and lung carcinoma.