Common upregulated genes were e.g. important for T cell immunobiology (ARG2 [51], SLC43A2 [52], IGFLR1 [53]), involved in cell migration (LAYN [54]) or known to be involved in cigarette smoke-induced pulmonary inflammation and autophagy in mice (EPHX2 [55]). The gene discussed is LAYN; the disease is inflammatory response.