The results indicated a significant increase in the mRNA and protein expression levels of the inflammatory cytokines IL-6, IL-10, and TNF-α 48 h after H37Rv-RFP infection compared with levels in the controls (hLO alone, M. tb-infected hLO, and hLO containing hMφs) (Fig 2C and 2D). The gene discussed is IL10; the disease is infection.