The oncogenic role of KIS in the progression of several types of cancer has been reported, such as gastric cancer (Feng et al. 2020), hepatocellular carcinoma (Wei et al. 2019) and ovarian cancer(Katchman et al. 2017); however, its expression pattern and functional role in LUAD remain unclear. The gene discussed is UHMK1; the disease is hepatocellular carcinoma.