After conducting an extensive literature review, we observed that cell division cycle 6 (CDC6) has been relatively underexplored in melanoma research compared to other prognostic genes, despite its implication in the initiation and progression of various human tumors (Wang et al. 2022; Mourkioti et al. 2023; Lim and Townsend 2020). The gene discussed is CDC6; the disease is melanoma.