In the multivariate analysis, age (P = 0.002, HR: 0.485 for DFS; P = 0.001, HR: 0.466 for OS), pTNM stage (P = 0.032, HR: 1.806 for DFS; P = 0.023, HR: 1.868 for OS), LN metastasis (P = 0.029, HR: 2.246 for DFS; P = 0.035, HR: 2.184 for OS), IKZF3 amplification (P = 0.006, HR: 2.286 for DFS; P = 0.004, HR: 2.416 for OS), tumor deposits (P < 0.001, HR: 1.322 for DFS; P < 0.001, HR: 1.300 for OS), vessel invasion (P = 0.04, HR: 1.611 for DFS; P = 0.03, HR: 1.655 for OS), and nerve invasion (P = 0.021, HR: 1.678 for DFS; P = 0.012, HR: 1.750 for OS) were associated with DFS and OS (Table 2). Here, IKZF3 is linked to neoplasm.