According to the research of Lawrence Fong et al., γδ+Vδ2+ T cells infiltrated by renal cell carcinoma can simultaneously express molecular markers such as PD-1, TIGIT, and Tim3, indicating that the antitumor immune response is inhibited, while such cells are not observed in normal tissues. The gene discussed is PDCD1; the disease is hereditary clear cell renal cell carcinoma.