CCN2 and gingival disorder: This is the first study to demonstrate that LLLT has a modulating effect on cell proliferation in gingival fibroblasts from tissues with gingival hyperplasia due to the use of calcium channel blockers without causing cytotoxicity and can suppress the synthesis of CTGF, TGF-β, and collagen—all of which have been linked to the pathogenesis of gingival hyperplasia.