Thus, aspects related to the natural course of infection described in theliterature point towards a slower progression for those related to HIV-1 straincontaining GWGR motif8, lower AIDS incidence27, higher CD4+ T cell counts, and lower RNA viral loads31, may be directly associated with a natural infection history before the cARTera, while the observed physicochemical aspects9-11,25, maybe insufficient currently in the face of new antiretroviral regimens tocause significant differences in the natural history of infection in theseindividuals. The gene discussed is CD4; the disease is infection.