Evaluation of proliferation indices demonstrated statistically higher Ki67 indices in adenoma groups [tubular adenoma 9.77 (95% CI, 9.61–11.80), tubulovillous adenoma 9.41 (95% CI, 8.91–10.76)] compared to both normal [6.96 (95% CI, 7.16–8.77)] and cancer groups [5.46 (95% CI, 6.55–8.99)] (P < 0.05). Here, MKI67 is linked to cancer.