CTHRC1 and malignant colon neoplasm: In colon cancer patients, expression of CTHRC1 was positively correlated with tumor infiltration depth (P ═ 0.019) and clinical stage (P ═ 0.034), while no significant correlation was found between CTHRC1 expression and patients’ age, gender, lymph node metastasis, or distant metastasis (P > 0.05) (Table 4).