In melanoma, immune cell infiltration, such as neutrophils and macrophages, was positively correlated with CTHRC1 expression, but the correlation of CTHRC1 expression with immune cell infiltration was not as significant as in colon cancer and thyroid cancer (respective correlation coefficients were smaller) (Figure 5A and 5B). Here, CTHRC1 is linked to malignant colon neoplasm.