However, as demonstrated in Figure S1 and Table S3, the protein levels of CTHRC1, immune cell markers, such as CD4, CD8, CD68, and CD69, and the proliferation marker Ki-67 were not significantly different between BRAF(V600E) mutant melanoma tissues and wild-type melanoma tissues (P > 0.05). The gene discussed is BRAF; the disease is melanoma.