In thyroid cancer, protein levels of CTHRC1 were also significantly higher in BRAF(V600E) mutant tissues compared with wild-type tissues (P ═ 0.009), and CD4-positive cells (P ═ 0.021), CD8-positive cells (P ═ 0.025), and CD69-positive cells (neutrophils) (P ═ 0.025) were more enriched in BRAF(V600E) mutant tissues compared with wild-type tissues. Here, CD4 is linked to thyroid cancer.