Next, the association of CTHRC1 expression with clinicopathological parameters in colon cancer, thyroid cancer, and melanoma patients (including age, gender, tumor size, tumor infiltration depth, lymph node metastasis, distant metastasis, and clinical stage) was analyzed based on the TCGA data. The gene discussed is CTHRC1; the disease is metastatic malignant neoplasm in the lymph nodes.