CTHRC1 and metastasis: In melanoma patients, significant correlations were found between OS rates and risk factors including age (HR ═ 1.74) (P < 0.001), tumor size (HR ═ 1.96) (P < 0.001), lymph node metastasis (HR ═ 1.82) (P < 0.001), distant metastasis (HR ═ 1.88) (P ═ 0.043), clinical stage (HR ═ 1.73) (P < 0.001), and CTHRC1 expression level (low and high) (HR ═ 0.71) (P ═ 0.017) (Table 3).