Moreover, enrichment analysis showed that CTHRC1 was associated with signaling pathways including osteoclast differentiation, Staphylococcus aureus infection, phagosome, heparin binding, glycosaminoglycan binding, extracellular matrix structural constituent, extracellular matrix component, collagen trimer, collagen-containing extracellular matrix, collagen fibril organization, extracellular structure organization, and extracellular matrix organization in colon cancer. Here, CTHRC1 is linked to staphylococcus aureus infection.