In melanoma patients, CTHRC1 expression was correlated with patient age (P ═ 0.026), but no significant correlation was found between CTHRC1 expression and patients’ gender, tumor size, lymph node metastasis, distant metastasis, or clinical stage (P > 0.05) (Table S1). The gene discussed is CTHRC1; the disease is metastatic malignant neoplasm in the lymph nodes.