As shown in Table 1, in colon cancer patients, significant correlations were observed between OS rates and risk factors, including depth of tumor infiltration (HR ═ 3.23) (P ═ 0.006), lymph node metastasis (HR ═ 2.73) (P < 0.001), distant metastasis (HR ═ 3.4) (P < 0.001), clinical stage (HR ═ 3.04) (P < 0.001), and CTHRC1 expression level (low and high) (HR ═ 1.56) (P ═ 0.036). The gene discussed is CTHRC1; the disease is metastatic malignant neoplasm in the lymph nodes.