In melanoma, CTHRC1 was associated with signaling pathways including focal adhesion, PI3K-Akt signaling pathway, ECM–receptor interaction, growth factor binding, glycosaminoglycan binding, extracellular matrix structural constituent, endoplasmic reticulum lumen, collagen trimer, collagen-containing extracellular matrix, aminoglycan metabolic process, extracellular structure organization, and extracellular matrix organization (Figure 4B). Here, AKT1 is linked to melanoma.