In thyroid cancer, CTHRC1 was associated with signaling pathways including ECM-receptor interaction, S. aureus infection, hematopoietic cell lineage, cytokine binding, extracellular matrix structural constituent conferring tensile strength, extracellular matrix structural constituent, external side of the plasma membrane, collagen trimer, collagen-containing extracellular matrix, T cell activation, extracellular structure organization, and extracellular matrix organization. Here, CTHRC1 is linked to thyroid cancer.