Among these 20 genes, TIMP1, IL27RA, LIF, ETV1, and CTHRC1 were the top five most significantly correlated with the BRAF(V600E) mutation in human colon cancer, thyroid cancer, and melanoma; and only CTHRC1 was identified to be statistically significantly associated with the prognosis of all three tumor types (data will be shown later) (Figure 1B). The gene discussed is TIMP1; the disease is colonic neoplasm.