For example, CSF/CSF-1R interactions have been shown to induce an immunosuppressive M2 phenotype in glioblastoma-associated microglia/macrophages, and blockade of CSF-1R improves survival in tumor-burdened mice (Kennedy et al., 2013; Pyonteck et al., 2013). The gene discussed is CSF1R; the disease is glioblastoma.