IRF7 and neoplasm: Given broad Irf gene expression in p53EPS tumors (Figure 2E, Figure 2—figure supplement 2, Figure 4—figure supplement 1, Supplementary file 5), as well as reports of IRF7 gene expression in human glioblastoma tumor cells, association with worsened patient outcome, and potential roles in tumor stem cell biology (Jin et al., 2012; Yang et al., 2022), we decided to investigate tumor cell-specific roles for Irf genes in p53EPS initiation.