IRF8 and neoplasm: Interestingly, we observed upregulation of several interferon regulatory factor (Irf) family members including irf7 and irf8 in p53EPS tumor-burdened brains (Figure 2B, Supplementary file 1, Supplementary file 2), suggesting potential roles for these master regulators of inflammation on immune-related responses during p53EPS tumorigenesis in vivo.