In p53EPS tumor brains with irf7 and irf8 knock-down, we observed reduced expression of genes associated with our inflammation signature in p53EPS tumor-burdened brains, including immune evasion-associated transcripts like suppressor of cytokine signaling 1a (socs1a) (Figure 4—figure supplement 1), suggesting reduced tumor-specific inflammation and associated immune evasion mechanisms, which were previously shown to be upregulated in response to anti-tumor cell infiltration (Gangoso et al., 2021). The gene discussed is IRF8; the disease is neoplasm.