IRF8 and neoplasm: We also performed p53EPS bulk tumor cell transplantations into the hindbrain ventricles of irf8 CRISPR/Cas9-injected syngeneic host zebrafish embryos at 2 dpf and observed 46% p53EPS tumor cell engraftment at 20 dpf, compared to 19% engraftment in irf8 wild-type host zebrafish (p=0.0002, Fisher’s exact test, Figure 5D), further supporting an inhibitory role for phagocytes within the TME.