Interestingly, we observed increased immune cell and inflammatory gene expression in both p53EPS tumor and stromal cell fractions compared to control unaffected whole brain tissue, including transcripts associated with myeloid cell types (mpeg1, irf7, irf8), lymphoid progenitor and specific subtype regulators (rag1, rag2, lck), stat1a/b, fas cell surface death receptor, and Toll-like receptor 4b (tlr4bb), among other genes involved in immune responses (adjusted p-value<0.0001, Figure 2E, Supplementary file 5). Here, IRF8 is linked to neoplasm.