STAT3 and brain neoplasm: Interestingly, 7 of the top 13 enriched gene sets identified (NOM p-value<0.05) related to inflammation or inflammatory signaling pathways, including the interferon gamma response, TNFA signaling, the interferon alpha response, and Jak/STAT3 signaling (Figure 2D, Supplementary file 4), suggesting a strong inflammatory component in our brain tumor model.