First, deleting Mst1&2 with an inducible acinar cell-specific Cre or overexpressing YAP1 in the pancreas reproduced the Mst1&2 whole pancreas epithelial knockout phenotype – acinar atrophy, ductal expansion, and pancreatitis-like phenotype (Gao et al., 2013). This evidence concerns the gene MST1 and pancreatitis.