CD82 is another TSPAN that has been implicated in cancer, where it is considered to be a suppressor of tumor metastasis by virtue of its role in regulating cell surface signaling (Miranti, 2009; Tsai and Weissman, 2011), endocytic trafficking (Odintsova et al., 2013), canonical signaling by the Wnt family of secreted glycolipoproteins (Chigita et al., 2012), cell adhesion (Abe et al., 2008) and migration (Ordas et al., 2021). This evidence concerns the gene TSPAN18 and neoplasm.