Considering that CXCL1 is among the most abundantly secreted chemokines by TAMs (Wang et al., 2020), this phenomenon may arise from the suppression of macrophage infiltration in tumours, given the limited influence of GW4869 treatment on CXCL1 secretion by breast cancer 4T1 cells (Figure S10). This evidence concerns the gene CXCL1 and breast cancer.