Furthermore, the exogenous addition of EV‐Apo significantly reversed the synergistic inhibition effect between BHS and paclitaxel on breast cancer growth and lung metastasis, and this effect could be partially mitigated or further enhanced by knocking down or overexpressing CXCL1 in EV‐Apo, respectively (Figure 10a,b). This evidence concerns the gene CXCL1 and breast carcinoma.