TOB1 and neoplasm: However, not all SVs near TOB1-AS1 led to alterations in TAD architecture; for example, in tumor a3edc9cc-f54a-4459-a5d0-097879c811e5, TOB1-AS1 was predicted to remain in its original TAD after a 4 Mb tandem duplication (Supplementary Figure S6B).