TOB1 and familial pancreatic carcinoma: In addition, we knocked down TOB1-AS1 in two other pancreatic cancer cell lines Panc 10.05 and PATU-8988S, both of which had high expression of TOB1-AS1 (Figure 5A and Supplementary Figure S13A), using two antisense oligonucleotides (ASOs) (Figure 6F).