Interestingly, the top fifteen genes up-regulated in HIV-TB+ART patients consisted of some down-regulated genes (AC007922.2, AC111000.4, LINC01013, and AL139020.1) from HIV-TB patients and the top fifteen down-regulated genes in HV-TB+ART consisted of some up-regulated genes (COL4A2-AS1, AC079210.1, MFA-AS1, and LINC01993) from HIV-TB patients. The gene discussed is COL4A2; the disease is tuberculosis.