A study by Yin et al. showed that curcumin has a direct inhibitory effect on NLRP3 inflammasome activation in macrophages from high-fat diet-induced insulin resistance in wide-type C57BL/6 mice, and NLRP3 deficiency abrogated curcumin inhibition of IL-1b and IL-18 production suggesting that the inhibitory effect of curcumin in SIRS may be related to its action in NLRP3 inflammasome [102]. The gene discussed is NLRP3; the disease is Insulin resistance.