In lipopolysaccharide (LPS)-induced ALI mouse models, glycoprotein markedly depressed LPS-induced lung wet/dry ratios, myeloperoxidase activity, malondialdehyde content, superoxide dismutase and glutathione peroxidase depletion and the contents of inflammatory cytokines IL-1β, IL-6 and TNF-α. Here, IL1B is linked to acute respiratory distress syndrome.