Given that the majority of published studies on TRPS1 immunohistochemical expression have predominantly focused on epithelial tumors, the aim of our study was to bring attention to a potential pitfall associated with the use of TRPS1 IHC in cutaneous mesenchymal tumors and tumors of uncertain differentiation frequently encountered in routine dermatopathology practice. Here, TRPS1 is linked to mesenchymal cell neoplasm.