ACE2 and chorioamnionitis: Interestingly, chorioamnionitis and intraamniotic infections have already been correlated in the literature with the upregulation of VEGF signaling at the maternal–fetal interface; thus, in the present study, placentae belonging to women who delivered one or more babies with IHs displayed a higher rate of chorioamnionitis and a remarkable hypo-expression of ACE2, with both indicating an increased activation of the VEGF pathway, as is commonly found in hypoxic settings [23].