ACE2 and isolated hemihyperplasia: In the end, the women from the study group turned out to be significantly older than the controls (mean age: 35.05 vs. 26.77; p < 0.001), thus not only supporting previous findings regarding advanced maternal age as a possible risk factor for IH but also suggesting that an older maternal age could be related to altered placental perfusion, as demonstrated by ACE2 hypo-expression [7].