A number of physiologic (stress, exercise, pregnancy, and breastfeeding) and pathologic conditions (cirrhosis, chronic kidney failure, primary hypothyroidism, compression of the pituitary stalk by a non-PRL-secreting pituitary tumor or different parasellar mass, and infiltration of the hypothalamus), as well as several drugs (antipsychotics, antidepressants, dopamine receptor blockers, dopamine synthesis inhibitors, and oral contraceptives) can induce symptomatic PRL level increase [9]. The gene discussed is PRL; the disease is chronic renal failure syndrome.