MAPT and Alzheimer disease: These are some cases where membranes are compromised due to AD, since the overexpression of Tau or its hyperphosphorylation, as well as the presence of amyloid peptides, may be responsible for a generalized failure at the cellular level; the endocytic pathway is affected, and the receptors involved in neurotransmission will also be damaged, either in their tertiary structure or in their intracellular transit [63], which could indicate that the rough endoplasmic reticulum is under stress [64].