LEP and Insulin resistance: Several factors have been advocated, such as the connection between adipocytes and inflammatory cells by means of cytokines and reactive oxygen species synthesis; the endocrine signaling pathways of adipocytes, both through action of androgens and gastrointestinal hormones, such as resistin, leptin, and visfatin; the meaning of the microbiome and its modifications in the scenario of obesity; the outcomes of insulin resistance and diabetes on cancer cell survival; individual genetic predisposition and/or epigenetic changes, etc. [8].