Furthermore, CBD was found to reduce the severity of 5-fluorouracil-induced oral mucositis in mice and human oral keratinocytes by upregulating the expression level of antioxidant enzymes, such as HO-1 and NQO1, as well as by increasing the expression of Nrf2 and its nuclear translocation, all effects being concomitant with a decrease in Keap1 activation (Nrf2 suppressor). Here, NFE2L2 is linked to oral mucositis.