Furthermore, in primary microglial cultures derived from Abcd1-null mice and from patients with X-linked adrenoleukodystrophy (X-ALD), the administration of JWH133 induced the Nrf2 antioxidant pathway and inhibited the ROS production elicited by excess very long-chain fatty acids [61]. This evidence concerns the gene ABCD1 and X-linked adrenoleukodystrophy.