LIFR knockdown on Caki-2 cells increased sensitivity to verteporfin (IC50 value = 10.38 vs. 16.91 μmol for control cell line), while a correlation analysis between drug sensitivity and LIFR mRNA levels on nine RCC cell lines in the CCLE database revealed a strong correlation for two drugs (PHA-665752 with r = 0.707, p = 0.033, PF2341066 with r = 0.707, p = 0.033). This evidence concerns the gene LIFR and renal cell adenocarcinoma.