DCLK1 and renal cell adenocarcinoma: Weygant et al. performed a methylation data analysis of 159 paired RCC plus normal adjacent tissues from TCGA–KIRC, which showed a strong DCLK1 promoter hypomethylation that could perform as a diagnostic biomarker in distinguishing cancerous tissue (Area Under Curve, AUC = 0.838 ± 0.024 for β-promoter) [21].