RCC cell lines with dysfunctional DAB2IP (knocked down 786-O cells, 786-O KD and Sut002 vector control, Sut002VC) showed higher resistance to temsirolimus compared to RCC cell lines with relatively functional DAB2IP (786-O and DAB2IP-expressing Sut002 cells, Sut002DAB2IP). The gene discussed is DAB2IP; the disease is renal cell adenocarcinoma.