However, PD-L1 expression in paracancerousor cancer nests was hardly detectable, likely due to Pin1 overexpressionpromoting the degradation of PD-L1.20 CD4+ and CD8+ T cell, macrophage, and natural killer(NK) cell infiltration were negatively correlated, and Treg infiltrationwas negatively correlated with Pin1 expression (Figures 2D and S3). Here, CD4 is linked to cancer.