Notably, these increases were matchedby corresponding decreases in the abundance of immunosuppressive Tregs(Figure 7D) and increasesin immunostimulatory PD-L1-positive immune cells (Figure 7E), consistent with a tumor-suppressiveTIME phenotype, as were increases in granzyme B+ CD8+ T cells and TNF-α+ and IFN-γ+ CD4+ T cells (Figure S32).Both treatments also decreased tumor Pin1 expression as measured byimmunofluorescence and ELISA results (Figures 7F, S33A and S34), and had inverse effects to increase the frequency of PD-L1+ cells in the TMEs of these mice (Figures 7F and S33B). This evidence concerns the gene PIN1 and neoplasm.