Through comprehensive bioinformatics analysisand clinical samplestudies, we have identified significant upregulation of Pin1 expressionin HCC, underscoring its pivotal role in driving cancer progression.Furthermore, targeted inhibition of Pin1 effectively suppresses tumorproliferation and exerts regulatory control over the expression ofPD-L1, thereby highlighting the promising potential of Pin1 inhibitionas a novel strategy for synergistic immunotherapy. The gene discussed is PIN1; the disease is hepatocellular carcinoma.