Unsupervised hierarchical clustering analysis of HepYF-M13 cells and human HCC cell lines showed that HepYF-M13 cells clustered mainly with mesenchymal-like human HCC cell lines of the CL3 transcriptomic subgroup, which includes less differentiated, highly proliferative and invasive liver cancer cells that express high levels of stemness and EMT markers (Caruso et al., 2019). Here, ADGRL3 is linked to hepatocellular carcinoma.