Reminiscent of human liver cancers that express both lineages (Brunt et al., 2018), we noted the upregulated expression of stemness markers such as Sox9, Sox4, Cd44, Prom1 and Cd24a in HepYF-M13 and HepYF-M14 cells compared to their expression in normal hepatocytes and H2.35 immortalized hepatocytes (Fig. 1F). This evidence concerns the gene CD44 and liver cancer.