Moreover, it has been demonstrated that the ATG12‐ATG3 complex (one of the ATG complexes which regulate autophagy) interacts with Alix (an ESCRT accessory protein), which regulates endosomal function and exosome biogenesis.45 One theory supports that LC3 protein and its family members are responsible for LC3‐dependent EV loading and secretion (LDELS) of miRNAs which is particularly interesting as miRNAs derived from exosomes possess regulatory roles in inflammatory processes.39 It is important to mention that, autophagy has been also described as deregulated process in RA. This evidence concerns the gene MAP1LC3A and rheumatoid arthritis.