A common target of these exosomal miRNAs, the SRSF4 has marked a decrease in synovial fluid, suggesting that along with miR-335-5p and miR-483-5p, they could be promising disease biomarkers.10 Other exosomal biomarkers, found in the serum of RA patients of a pilot study, were the exomiR-451a and exomiR-25-3p which along with the sTWEAK protein, correctly classified 95.6% of patients in the early disease stage. Here, SRSF4 is linked to rheumatoid arthritis.