The same study confirmed that FLS-EVs contain citrullinated peptides and IgG, suggesting that they also become autoantigens in RA.12 Furthermore, a recent proteomic analysis of CD4+ T cells derived EVs revealed the upregulation of DPYSL3 and downregulation of PSME1 in RA patients. The gene discussed is PSME1; the disease is rheumatoid arthritis.