The same study indicates that exosomes which originate from TNF-α stimulated FLSs in RA, can suppress the proliferation and migration of chondrocytes, thus suggesting a therapeutic potential of the exosomes.35 Exosomes and their miRNA have been also linked with the imbalance of T-regulatory cells (Tregs)/Th cells and Tregs homeostasis. Here, TNF is linked to rheumatoid arthritis.