Figure 1 illustrates that in addition to its notable target at the serotonin reuptake transporter (SERT), it has an appreciable affinity for the norepinephrine transporter (NET), central muscarinic (M1) receptors, nitric oxide synthase (NOS) (8), and CYP 2D6 (6, 9). Some research also suggests paroxetine additionally has activity at CYP 3A4 (10). As a consequence of the lack of specificity, paroxetine, compared to other SSRIs, results in increased sedation, constipation, sexual dysfunction, discontinuation syndrome, and weight gain (11). The gene discussed is SLC6A2; the disease is sexual dysfunction.